Inhibitory Action of Troglitazone, an Insulin-Sensitizing Agent, on the Calcium Current in Cardiac Ventricular Cells of Guinea Pig

この論文にアクセスする

この論文をさがす

著者

抄録

We investigated the effects of troglitazone, a new orally active hypoglycemic agent, on the voltage-dependent L-type Ca<SUP>2+</SUP> current in single cardiac ventricular myocytes of guinea pigs by the whole-cell voltage clamp technique.Troglitazone blocked the Ca<SUP>2+</SUP> currents in a concentration-dependent manner.The inhibitory effect was more potent at the holding potential(HP)of −50mV than at −80mV.The half-maximum inhibiting concentration(IC<SUB>50</SUB>)of troglitazone was 0.8μM with the Hill coefficient of 0.84 at −50mV HP.In contrast, the IC<SUB>50</SUB> value was higher than 10μM at −80mV HP.These results suggest that troglitazone at therapeutic concentrations inhibit the Ca<SUP>2+</SUP> channels and may exert cardioprotective effects in diabetic conditions.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 82(2), 102-109, 2000-02-01

    公益社団法人 日本薬理学会

参考文献:  30件中 1-30件 を表示

各種コード

  • NII論文ID(NAID)
    10008182980
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5283877
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ