Effects of Topically Applied Capsaicin Cream on Neurogenic Inflammation and Thermal Sensitivity in Rats

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The effects of capsaicin cream on neurogenic inflammation and thermal nociceptive threshold were investigated in rats.Firstly, for topical application of capsaicin cream to hind paw, we shaped boots from dental cement to prevent the animals from licking off the drug.Capsaicin cream(1%) led to significant increases in the amounts of Evans blue and substance P(SP) released into the perfusate, and the former response was significantly suppressed by pretreatment with RP67580, an NK<SUB>1</SUB>-receptor antagonist, but not by treatment with an NK<SUB>2</SUB>-receptor antagonist.Subsequent electrical stimulation of the sciatic nerve resulted in a significant reduction in Evans blue and SP extravasation 24h after topical application of capsaicin cream.On the other hand, when capsaicin cream was repeatadly applied to both hind paws once a day, withdrawal latency for noxious heat stimulation decreased after 24h, and this thermal hyperalgesia was reversed 3 days later.These results suggest that capsaicin cream initially affects neurogenic inflammation mechanisms and then blocks the pain transmission mechanism.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 82(2), 116-121, 2000-02-01

    公益社団法人 日本薬理学会

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各種コード

  • NII論文ID(NAID)
    10008183031
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5283904
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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