Effects of a Novel Vesamicol Receptor Ligand, m-(Iodobenzyl)trozamicol, on the Canine Isolated, Blood-Perfused Atrioventricular Node Preparation

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m-(Iodobenzyl)trozamicol(MIBT)is a recently discovered vesamicol analgoue.It has been shown that radiolabelled [<SUP>125</SUP>I]MIBT can be used as a marker of cholinergic innervation in the heart as well as in the brain.The purpose of this study was to analyze the direct effects of MIBT on the atrioventricular and intraventricular conduction in addition to the coronary blood flow using the canine isolated, blood-perfused atrioventricular node preparation.Intracoronary administration of MIBT suppressed the atrioventricular and intraventricular conduction, while it increased the coronary blood flow.The effect and duration of action on the intraventricular conduction was less pronounced compared with other effects.Moreover, the doses of MIBT needed to cause negative dromotropic and coronary vasodilator effects in this study was much greater than those needed for imaging the cardiac cholinergic innervation.Pretreatment of the preparations with a muscarinic receptor antagonist, atropine, did not block these effects of MIBT, suggesting that MIBT may possess muscarinic receptor-independent ion channel activity in the cardiac conduction system and coronary arteries.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 82(2), 150-154, 2000-02-01

    公益社団法人 日本薬理学会

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各種コード

  • NII論文ID(NAID)
    10008183192
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5283963
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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