1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) Inhibits Cyclic GMP-PKG Pathway-Independent Nonadrenergic, Noncholinergic Relaxation in Longitudinal Muscle of the Rectum of Wistar-ST Rats

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著者

    • Nakagawa Masashi NAKAGAWA Masashi
    • Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Science and Technology, Osaka Prefecture University
    • Niioka Satomi [他] NIIOKA Satomi
    • Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Science and Technology, Osaka Prefecture University
    • YAMAJI Michiru
    • Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Science and Technology, Osaka Prefecture University
    • OKISHIO Yutaka
    • Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Science and Technology, Osaka Prefecture University
    • NISHIO Hideaki
    • Department of Veterinary Pharmacology, College of Agriculture, Research Institute for Advanced Science and Technology, Osaka Prefecture University
    • HATA Fumiaki
    • Department of Veterinary Pharmacology, College of Agriculture and Department of Molecular Physiology and Biochemistry, Research Institute for Advanced Science and Technology, Osaka Prefecture University

抄録

Participation of the nitric oxide-cyclic GMP pathway in nonadrenergic, noncholinergic(NANC)relaxation induced by electrical field stimulation of longitudinal muscle of the rectum of Wistar-ST rats was studied by using a selective inhibitor of soluble guanylyl cyclase, 1H-[1, 2, 4]oxadiazolo[4, 3-a]quinoxalin-1-one(ODQ).ODQ concentration dependently inhibited the relaxation and at 10μM, maximally inhibited it by 83%.However, results obtained with N<SUP>G</SUP>-nitro-L-arginine, L-arginine and exogenously added nitric oxide excluded the participation of nitric oxide in the relaxation.An inhibitor of cyclic GMP-dependent protein kinase(PKG)partially(39%)inhibited the relaxation.ODQ also significantly inhibited the relaxation, which persisted after the PKG inhibitor-treatment, by 85%.The results strongly suggest that ODQ inhibits the NANC relaxation in a cyclic GMP-PKG pathway-independent manner.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 82(2), 164-167, 2000-02-01

    公益社団法人 日本薬理学会

参考文献:  15件中 1-15件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10008183237
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5284002
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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