Involvement of Nitric Oxide From Nerves on Diarrhea Induced by Castor Oil in Rats

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抄録

Nitric oxide(NO)is involved in the mechanism of castor oil-induced diarrhea.This study was performed to elucidate the source of NO.Diarrhea was induced by oral administration of castor oil in rats.Diarrhea was significantly inhibited by the pre-treatment with a relatively selective nerve NO synthase inhibitor, 7-nitroindazole.This effect was attenuated by the treatment with L-arginine.Capsaicin-sensitive afferent nerve degeneration did not affect the diarrhea.N<SUP>G</SUP>-Nitro-L-arginine methylester significantly inhibited diarrhea even in capsaicin-pretreated rats.These data suggest, a least in part, the involvement of NO from nerves on the diarrhea induced by castor oil in rats.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 82(2), 168-170, 2000-02-01

    公益社団法人 日本薬理学会

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各種コード

  • NII論文ID(NAID)
    10008183253
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5284015
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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