Protease-Activated Receptor (PAR), a Novel Family of G Protein-Coupled Seven Trans-membrane Domain Receptors: Activation Mechanisms and Physiological Roles

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The protease-activated receptor(PAR)belongs to the large superfamily of G-protein-coupled seven trans-membrane domain receptors.The activation of PARs is achieved by proteolytic unmasking of the cryptic N-terminal receptor-activating sequence that binds to the body of the same receptor molecule.PARs-1, -3 and -4 are activated by thrombin, while PAR-2 is activated by trypsin or mast cell tryptase, but not by thrombin.PARs are weidely distributed to a variety of tissues and participate in a number of physiological or pathophysiological phenomena such as platelet aggregation, inflammation and cardiovascular, digestive or respiratory functions.Thus, PARs are of physiological importance and also of pharmacological interest as the novel target for drug development.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 82(3), 171-174, 2000-03-01

    公益社団法人 日本薬理学会

参考文献:  36件中 1-36件 を表示

被引用文献:  13件中 1-13件 を表示

各種コード

  • NII論文ID(NAID)
    10008183269
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00215198
  • NDL 記事登録ID
    5320967
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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