Effects of Nitric Oxide Scavenger, Carboxy-PTIO on Endotoxin-Induced Alterations in Systemic Hemodynamics in Rats

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The present experiments were conducted to clarify the mode of cardiovascular action of carboxy-2-phenyl-4, 4, 5, 5-tetramethylimidazoline-1-oxyl-3-oxide(carboxy-PTIO), a nitric oxide(NO)scavenger, during rat endotoxic shock by determining cardiac output and systemic arterial tone simultaneously.Lipopolysaccharide(LPS)(10mg/kg, i.v.) decreased systemic blood pressure and cardiac output with transient increases in hematocrit and total vascular resistance.Administration of carboxy-PTIO(1.7mg·kg<SUP>-1</SUP>·min<SUP>-1</SUP>, i.v.for 60min) at 90min after LPS attenuated further decline in blood pressure and cardiac output without affecting changes in hematocrit or total vascular resistance.It is concluded that carboxy-PTIO attenuates endotoxin-induced hypotension predominantly by maintaining cardiac output in rat experimental endotoxic shock.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 82(3), 261-264, 2000-03-01

    公益社団法人 日本薬理学会

参考文献:  15件中 1-15件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008183637
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5321099
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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