Effects of Nitric Oxide Scavenger, Carboxy-PTIO on Endotoxin-Induced Alterations in Systemic Hemodynamics in Rats.
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- Miura Katsuyuki
- Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
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- Yamanaka Shinya
- Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
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- Ebara Tsuneyuki
- Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
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- Okumura Michiaki
- Osaka City General Hospital,Osaka 534-0021,Japan
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- Imanishi Masahito
- Osaka City General Hospital,Osaka 534-0021,Japan
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- Kim Shokei
- Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
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- Nakatani Tatsuya
- Department of Urology,Osaka City University Medical School,Osaka 545-8585,Japan
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- Iwao Hiroshi
- Department of Pharmacology, Osaka City University Medical School,Osaka 545-8585,Japan
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Abstract
The present experiments were conducted to clarify the mode of cardiovascular action of carboxy-2-phenyl-4, 4, 5, 5-tetramethylimidazoline-1-oxyl-3-oxide(carboxy-PTIO), a nitric oxide(NO)scavenger, during rat endotoxic shock by determining cardiac output and systemic arterial tone simultaneously.Lipopolysaccharide(LPS)(10mg/kg, i.v.) decreased systemic blood pressure and cardiac output with transient increases in hematocrit and total vascular resistance.Administration of carboxy-PTIO(1.7mg·kg-1·min-1, i.v.for 60min) at 90min after LPS attenuated further decline in blood pressure and cardiac output without affecting changes in hematocrit or total vascular resistance.It is concluded that carboxy-PTIO attenuates endotoxin-induced hypotension predominantly by maintaining cardiac output in rat experimental endotoxic shock.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 82 (3), 261-264, 2000
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390282679261615104
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- NII Article ID
- 10008183637
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DC%2BD3cXitFOiu7o%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 5321099
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- PubMed
- 10887957
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I5321099
- https://api.elsevier.com/content/article/PII:S0021519819306924?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819306924?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/82/3/82_3_261/_pdf
- https://search.jamas.or.jp/link/ui/2000170655
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed