Metabolic Abnormalities Caused by 3-Acetylpyridine in the Cerebral Motor Regions of Rats: Partial Recovery by Thyrotropin-Releasing Hormone

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Although 3-acetylpyridine(3-AP) induces several motor disturbances and it degenerates the olivocerebellar pathway, abnormalities caused by 3-AP in cerebral motor regions remain to be elucidated.Here we investigated the metabolic changes caused by 3-AP(75mg/kg, i.p.) on local cerebral glucose utilization(LCGU) in various brain regions.The effects of anti-ataxic agents, thyrotropin-releasing hormone(TRH)(10mg/kg, i.p.) and its mimetic agent taltirelin hydrate(1mg/kg, i.p.), on the 3-AP-induced change in LCGU were also investigated.The LCGU in the nuclei of the basal ganglia, thalamus, limbic structures and brainstem of 3-AP-treated rats was significantly lower than that of naive animals.However 3-AP increased the LCGU of the cerebellar nuclei.TRH restored depressed LCGU in the substantia nigra and ventral tegmental area.TRH tended to restore the lowered LCGU in several nuclei of 3-AP-treated rats.Moreover, taltirelin further increased the LCGU in the cerebellar nuclei.These results suggest that the motor disturbance of the 3-AP-treated rats may be due to not only degeneration of the olivocerebellar pathway but also dysfunction of the several areas that play a role in motor coordination.Moreover, the anti-ataxic action by TRH could result from metabolic restoration of the multiple motor-coordination-related areas.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 82(4), 295-300, 2000-04-01

    公益社団法人 日本薬理学会

参考文献:  28件中 1-28件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008183803
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5362719
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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