Effects of Inhaled Low Molecular Weight Heparin on Airway Allergic Inflammation in Aerosol-Ovalbumin-Sensitized Guinea Pigs

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Low molecular weight, heparin(LMWH)possesses multiple nonanticoagulant properties.In the present study, we observed its anti-airway allergic inflammatory effects by bronchoalveolar lavage in guinea pigs.Guinea pigs were sensitized by repeatedly inhaling aerosolized ovalbumin.LMWH(400u/l, 800u/l), dexamethasone(1.2mg/l)or vehicle(normal saline)was inhaled for 7 days.Then the animals were sacrificed under anesthesia and then lavaged with ice-cold Hank's buffer immediately;bronchoalveolar lavage fluid(BALF)was prepared 24h afterr the animals were challenged by antigen exposure.The effects of LMWH on total cell counts, absolute eosinophil counts and cell catalogues in BALF were studied;effects on the activity of eosinophil peroxidase(EPO)and the contents of histamine and eosinophil cationic protein(ECP)in BALF supernatant were detected.Our results showed that compared with the vehicle group, LMWH at 400u/l and 800u/l could significantly reduce total cell counts, absolute eosinophil counts and percentage of eosinophils in BALF(P<0.05 and P<0.01, respectively);LMWH at 800u/l markedly inhibited the activity of EPO in BALF supernatant(P<0.05);LMWH at 400u/l and 800u/l remarkably reduced the content of histamine in BALF supernatant(P<0.05 and P<0.01, respectively), LMWH at 800u/l decreased the content of ECP(P<0.05)significantly.It suggested that LMWH exerted anti-airway allergic inflammatory action by inhibiting infiltration of inflammatory cells and reducing release of inflammatory mediators, as well as antagonizing their activities, and that LMWH could be developed as a potential anti-bronchial asthmatic drug.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 82(4), 326-330, 2000-04-01

    公益社団法人 日本薬理学会

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各種コード

  • NII論文ID(NAID)
    10008183940
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5362798
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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