Effect of Zaldaride Maleate, an Antidiarrheal Compound, on Fecal Pellet Output Induced by Hyperpropulsion in Gastrointestine of Rats

この論文にアクセスする

この論文をさがす

著者

抄録

The effect of zaldaride, a calmodulin inhibitor, on fecal pellet output in rats was compared with that of loperamide, an antidiarrheal drug.5-Hydroxytryptamine(10mg/kg, s.c.), neostigmine(0.3mg/kg, s.c.)and nicotine(1.0mg/kg, s.c.)increased fecal pellet output.Zaldaride(≥30mg/kg, p.o.)reduced these increases in facal pellet outputs.Loperamide(10mg/kg, p.o.)inhibited fecal pellet output induced by 5-hydroxytryptamine and neostigmine but not nicotine.Under normal conditions, zaldaride and loperamide did not affect fecal pellet output at doses used in these studies.In conclusion, zaldaride may inhibit increases in fecal pellet output induced by hyperpropulsion of the gastrointestinal tract without causing constipation as a side effect.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 82(4), 350-352, 2000-04-01

    公益社団法人 日本薬理学会

参考文献:  15件中 1-15件 を表示

各種コード

  • NII論文ID(NAID)
    10008184040
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5362831
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ