New Approach for Measurement of Sympathetic Nervous Abnormality in Conscious, Spontaneously Hypertensive Rats

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著者

    • INA Yasuhiro
    • Drug Development Research Laboratories, Pharmaceutical Research, Institute, Kyowa Hakko Kogyo Co., Ltd
    • NAGASHIMA Ken
    • Drug Development Research Laboratories, Pharmaceutical Research, Institute, Kyowa Hakko Kogyo Co., Ltd
    • OHMORI Kenji
    • Drug Development Research Laboratories, Pharmaceutical Research, Institute, Kyowa Hakko Kogyo Co., Ltd
    • KOBAYASHI Satoshi
    • Drug Development Research Laboratories, Pharmaceutical Research, Institute, Kyowa Hakko Kogyo Co., Ltd
    • IMAI Kazuhiro
    • Department of Bio-Analytical Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo

抄録

We previously reported a highly sensitive chemiluminescence high−performance liquid chromatographic method to determine catecholamines in plasma.In this study, we employed this method to measure the cardiac function and plasma norepinephrine(NE)concentration in conscious rats.Benidipine, 1, 4−dihydropyridine calcium antagonist(4 mg/kg), and β−blocker(propranolol, 30 mg/kg)were administered orally to conscious spontaneously hypertensive rats(SHRs)and Wistar−Kyoto(WKY)rats, and blood pressure, heart rate and plasma NE levels were measured.Plasma NE concentration was used as an index of sympathetic nervous system activity in conscious rats.The basal plasma NE levels were significantly higher in SHRs than in WKY rats(P<0.05), indicating the activity of the basal sympathetic nervous system in SHRs was elevated.The sensitivity of the baroreflex−mediated sympathetic nervous response was reduced in SHRs as compared to that in WKY rats.The concomitant administration of benidipine and a β−blocker decreased heart rate without affecting the baroreflex−mediated sympathetic nervous response, indicating that propranolol might suppress mainly the cardiac β−adrenoceptor.The present study suggested the high activity of the basal sympathetic nervous system and the reduced response of the baroreflex−mediated sympathetic nervous system in SHRs compared to WKY rats in the conscious condition.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 83(1), 39-45, 2000-05-01

    公益社団法人 日本薬理学会

参考文献:  29件中 1-29件 を表示

被引用文献:  3件中 1-3件 を表示

各種コード

  • NII論文ID(NAID)
    10008184318
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5399697
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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