Effects of Angiotensin-Converting Enzyme Inhibitors on Spontaneous or Stimulated Generation of Reactive Oxygen Species by Bronchoalveolar Lavage Cells Harvested From Patients With or Without Chronic Obstructive Pulmonary Disease

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We examined the effects of angiotensin−converting enzyme(ACE)inhibitors on spontaneous or stimulated generation of reactive oxygen species(ROS)by bronchoalveolar lavage(BAL)cells prepared from 6 patients with chronic obstructive pulmonary disease(COPD)and from age−matched control subjects without COPD.The ROS produced by BAL cells were measured by the lucigenin−dependent chemiluminescence method.The application of ACE inhibitors into culture media containing BAL cells inhibited spontaneous and stimulated generation of ROS by BAL cells from COPD patients and control subjects in an ambroxol−concentration−dependent manner.Alacepril, an ACE inhibitor bearing SH−group, inhibited the oxygen radical production and generation by BAL cells from COPD patients in a dose−dependent fashion.Approximately 0.6−0.7 mM of alacepril inhibited 50% of the ROS production by BAL cells from COPD patients, whereas a slightly higher concentration(3 mM)of lisinopril, an ACE inhibitor not bearing an SH−group, was necessary to inhibit the production of ROS.These results suggest that an ACE inhibitor may act as an pulmonary antioxidant in patients with COPD.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 83(1), 56-62, 2000-05-01

    公益社団法人 日本薬理学会

参考文献:  37件中 1-37件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008184374
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5399713
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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