Decrease of Sexual Receptivity by Prolylendopeptidase Inhibitor in Female Rats

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抄録

The effects of a prolylendopeptidase inhibitor, 1−[3−(2−indanylanylacetyl)−L−thioprolyl]pyrrolidine(Z−321), on lordosis behavior were investigated in estrogen and progestrone−treated ovariectomized rats.Females were orally administered 100, 200 or 300 mg/kg Z−321 or the vehicle(control).The mean lordosis quotient in the rats given 300 mg/kg Z−321 was lower than that in control group, but that in rats given 100 or 200 mg/kg Z−321 was not lower.Thus, Z−321 suppressed lordosis in estrogen and progesterone−treated ovariectomized rats.Peptide neurotransmitters, especially those containing proline, are though to be involved in the inhibitory mechanisms for lordosis behavior.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 83(1), 82-85, 2000-05-01

    公益社団法人 日本薬理学会

参考文献:  17件中 1-17件 を表示

各種コード

  • NII論文ID(NAID)
    10008184471
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5399729
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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