Roles of Prostanoids Revealed From Studies Using Mice Lacking Specific Prostanoid Receptors

この論文にアクセスする

この論文をさがす

著者

抄録

The actions of prostanoids in various physiological and pathophysiological conditions have been being examined using mice lacking different prostanoid receptors.Prostaglandin(PG)I<SUB>2</SUB> worked not only as a mediator of inflammation but also as an antithrombotic agent.PGF<SUB>2α</SUB> was found to be an essential inducer of labor.Several important actions of PGE<SUB>2</SUB> are exerted via each of the four PGE<SUB>2</SUB> receptor subtypes:EP<SUB>1</SUB>, EP<SUB>2</SUB>, EP<SUB>3</SUB> and EP<SUB>4</SUB>.PGE<SUB>2</SUB> participated in colon carcinogenesis via the EP<SUB>1</SUB>.PGE<SUB>2</SUB> also participates in ovulation and fertilization and contributes to the control of blood pressure under high−salt intake via the EP<SUB>2</SUB>.PGE<SUB>2</SUB> worked as a mediator of febrile responses to both endogenous and exogenous pyrogens and as a regulator of bicarbonate secretion induced by acid−stimulation in the duodenum via the EP<SUB>3</SUB>.It regulated the closure of ductus arteriosus and showed bone resorbing action via the EP<SUB>4</SUB>.PGD<SUB>2</SUB> was found to be a mediator of allergic asthma.These studies have revealed important roles of prostanoids, some of which had not previously been known.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 83(4), 279-285, 2000-08-01

    公益社団法人 日本薬理学会

参考文献:  61件中 1-61件 を表示

被引用文献:  6件中 1-6件 を表示

各種コード

  • NII論文ID(NAID)
    10008184505
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00215198
  • NDL 記事登録ID
    5501156
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ