Influences of Everninomicin, Vancomycin and Teicoplanin on Chemical Mediator Release From Rat Peritoneal Mast Cells

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We examined influences of certain antibiotics on the release of chemical mediators from isolated rat peritoneal mast cells in vitro.Isolated peritoneal mast cells were obtained from male Wistar strain rats.Everninomicin(0.06−1.2 mg/ml), vancomycin(0.05−1.0 mg/ml), teicoplanin(0.07−1.4 mg/ml)and concanavalin A(0.01 mg/ml)were used.Isolated mast cells were incubated in the presence of various concentrations of the test compound at 37°C for 10 min.Histamine contents of the supernatant and cell pellet were measured by an automated fluorometric method.Prostaglandin D<SUB>2</SUB>(PGD<SUB>2</SUB>)contents of the supernatant were determined by enzyme immunoassay.Everninomicin(0.06−1.2 mg/ml)had no influence on histamine and PGD<SUB>2</SUB> release from mast cells.On the other hand, vancomycin significantly released both histamine(0.5 and 1.0 mg/ml)and PGD<SUB>2</SUB>(1.0 mg/ml)from mast cells, but vancomycin did not affect concanavalin A−induced histamine and PGD<SUB>2</SUB> release.Teicoplanin(more than 0.07 mg/ml)significantly stimulated histamine and PGD<SUB>2</SUB> release from mast cells and it also significantly potentiated concanavalin A−induced histamine and PGD<SUB>2</SUB> release.These results suggest that everninomicin causes no chemical mediator release from mast cells, different from vancomycin and teicoplanin.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 83(4), 300-305, 2000-08-01

    公益社団法人 日本薬理学会

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各種コード

  • NII論文ID(NAID)
    10008184624
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5501181
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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