Serum-Deprivation Induces Cell Death of Rat Cultured Microglia Accompanied With Expression of Bax Protein

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著者

    • Kimura Yuji KIMURA Yuji
    • Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
    • WAKAMATSU Daisuke
    • Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
    • KOZAKI Ryo-hei
    • Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
    • HASHIMOTO Hitoshi
    • Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
    • MATSUDA Toshio
    • Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
    • BABA Akemichi
    • Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University

抄録

Expression of Bcl−2 related proteins in rat microglial primary culture was examined.At relative low cell densities, serum deprivation caused cell death and nuclei condensation of cultured microglia.Expression of a pro−apoptotic protein, Bax, but not Bcl−2, was increased by the serum deprivation.SB203580, a specific inhibitor of p38<SUP>MAPK</SUP>, prevented both the serum deprivation−induced Bax expression and microglial death.Immunochemical staining showed that microglia expressing a high level of Bax were subjected to apoptosis−like cell death.These observations suggest that Bax expression underlies the apoptosis of cultured microglia after serum deprivation.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 83(4), 351-354, 2000-08-01

    公益社団法人 日本薬理学会

参考文献:  14件中 1-14件 を表示

被引用文献:  2件中 1-2件 を表示

キーワード

各種コード

  • NII論文ID(NAID)
    10008184843
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5501315
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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