Food Deprivation Depletes Gastric Mucus Glycoprotein in Streptozotocin-Induced Diabetic Rats

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Fasting causes gastric mucosal damage in streptozotocin(STZ)−induced diabetic rats, but its pathogenic mechanism remains to be elucidated.The aim of the present study was to investigate the alteration of gastric mucosal mucin, one of the gastric defensive factors against the developmet of such damage.Diabetes was induced in rats by intravenous injection of STZ(65 mg/kg).The experiments were performed using 4−week STZ−diabetic rats with blood glucose levels above 350 mg/dl.The amount of gastric mucus glycoprotein was determined by gel filtration, and the distribution of neutral and acidic mucins in the stomach epithelium was examined by histochemical analysis.In normal rats, 24−h fasting neither affected the gastric mucin content nor caused any macroscopic gastric mucosal injury.In contrast, starvation significantly reduced the amount of total gastric mucus glycoprotein prior to the formation of mucosal lesions in the STZ−diabetic rats.Nine hours after food deprivation, the gastric damage developed in about 70% of the diabetic rats, the amount of mucus glycoprotein markedly decreased, and both the neutral and acidic mucins diminished in the epithelium.Taken together, in STZ−diabetic rats, fasting by itself depletes gastric mucus glycoprotein, and this depletion may be involved in the pathogenic mechanism of the formation of gastric mucosal lesions.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(1), 51-55, 2000-09-01

    公益社団法人 日本薬理学会

参考文献:  19件中 1-19件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008185130
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5526075
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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