Serotonin Induces Apoptosis in PGT-β Pineal Gland Tumor Cells

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Serotonin−induced neuronal cell death has been implicated as a possible cause of neurodegenerative and neuropsychiatric disorders.To investigate the involvement of serotonin−induced apoptosis as a potential mechanism in the pathophysiology of serotonin−related diseases, MTT(3−(4, 5−dimethylthiazol−2−yl)−2, 5−diphenyltetrazolium bromide)assay, DAPI(4', 6−diamidino−2−phenylindole)staining, TUNEL(terminal deoxynucleotidyl transferase−mediated dUTP−biotin nick end labeling)assay and flow cytometric analysis were performed using the immortalized pineal cell line PGT−β.Through morphological and biochemical analyses, it was demonstrated that cell death induced by serotonin in PGT−β cells shows classic apoptotic features.These data suggest that serotonin induces apoptosis in PGT−β cells.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(1), 71-74, 2000-09-01

    公益社団法人 日本薬理学会

参考文献:  15件中 1-15件 を表示

被引用文献:  2件中 1-2件 を表示

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各種コード

  • NII論文ID(NAID)
    10008185219
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5526094
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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