Cardiac Angiotensin II Receptors Are Downregulated by Chronic Angiotensin II Infusion in Rats

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抄録

We studied the effect of chronic(7 days)angiotensin II infusion in a subpressor(200ng/kg per minute)dose on angiotensin II receptors in the left ventricle in rats.Infusion of angiotensin II caused an elevation in systolic blood pressure after 3 days, usually to values of about 150 mmHg, and the increase continued during the drug administration.The number of angiotensin II type 1 and angiotensin II type 2 receptors was significantly decreased by 20−30% in the angiotensin II−infused left ventricular membranes without affecting the affinity.Thus, these data suggest that angiotensin II may regulate the number of its own receptors in rat left ventricles.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(1), 75-77, 2000-09-01

    公益社団法人 日本薬理学会

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各種コード

  • NII論文ID(NAID)
    10008185235
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5526103
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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