Cardiac Angiotensin II Receptors Are Downregulated by Chronic Angiotensin II Infusion in Rats.

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  • Katoh Makoto
    Discovery Research Laboratory,Tanabe Seiyaku Co.,Ltd.,2-2-50,Kawagishi,Toda,Saitama 335-8505,Japan The Department of Cardiovascular Medicine,Kyushu University Faculty of Medicine,3-3-1,Maidashi,Higashi-ku,Fukuoka 812-8582,Japan
  • Egashira Kensuke
    The Department of Cardiovascular Medicine,Kyushu University Faculty of Medicine,3-3-1,Maidashi,Higashi-ku,Fukuoka 812-8582,Japan
  • Takeshita Akira
    The Department of Cardiovascular Medicine,Kyushu University Faculty of Medicine,3-3-1,Maidashi,Higashi-ku,Fukuoka 812-8582,Japan

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  • Cardiac Angiotensin 2 Receptors Are Downregulated by Chronic Angiotensin 2 Infusion in Rats

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Abstract

We studied the effect of chronic(7 days)angiotensin II infusion in a subpressor(200ng/kg per minute)dose on angiotensin II receptors in the left ventricle in rats.Infusion of angiotensin II caused an elevation in systolic blood pressure after 3 days, usually to values of about 150 mmHg, and the increase continued during the drug administration.The number of angiotensin II type 1 and angiotensin II type 2 receptors was significantly decreased by 20−30% in the angiotensin II−infused left ventricular membranes without affecting the affinity.Thus, these data suggest that angiotensin II may regulate the number of its own receptors in rat left ventricles.

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