Effect of Mexiletine on Thermal Allodynia and Hyperalgesia in Diabetic Mice

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著者

    • Kamei Junzo KAMEI Junzo
    • Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University
    • Zushida Ko ZUSHIDA Ko
    • Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University

抄録

The antinociceptive effect of mexiletine in diabetic mice was examined.Tail−flick latencies at heat intensity of 35 and 50 V in diabetic mice were shorter than those in non−diabetic mice.In diabetic mice, mexiletine increased the tail−flick latency at 35 V to the level observed in non−diabetic mice.The tail−flick latency at 50 V in diabetic mice, but not in non−diabetic mice, was increased by pretreatment with capsaicin(0.56 nmol, i.t., 24 h).The antinociceptive effect of mexiletine in diabetic mice was reduced by capsaicin.These results suggest that the mexiletine−induced antinociception in diabetic mice involves the inhibition of the nociceptive transmission of capsaicin−sensitive primary afferent fibers.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(1), 89-92, 2000-09-01

    公益社団法人 日本薬理学会

参考文献:  15件中 1-15件 を表示

被引用文献:  2件中 1-2件 を表示

キーワード

各種コード

  • NII論文ID(NAID)
    10008185298
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5526134
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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