SK4 Encodes Intermediate Conductance Ca^<2+>-Activated K^+ Channels in Mouse Urinary Bladder Smooth Muscle Cells

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著者

    • Ohya Susumu OHYA Susumu
    • Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
    • MURAKI Katsuhiko
    • Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
    • WATANABE Minoru
    • Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
    • IMAIZUMI Yuji
    • Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University

抄録

The single channel current of intermediate conductance Ca<SUP>2+</SUP>−activated K<SUP>+</SUP> channel(IK channel)was measured in mouse urinary bladder myocytes(MBM), and the molecular basis of the channel was suggested to be the SK4 subtype by RT−PCR.Among Ca<SUP>2+</SUP>−activated K<SUP>+</SUP> channel subtypes(SK2, SK3, SK4 and BK), the mRNAs of SK4 and BK were predominantly expressed in MBM.IK channel currents recorded from MBM showed:38.7 pS slope conductance under symmetrical 140 mM K<SUP>+</SUP> conditions, Ca<SUP>2+</SUP>−dependent activation, and blockade by charybdotoxin and econazole.These results strongly suggest that SK4 encodes IK channels in MBM.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(1), 97-100, 2000-09-01

    公益社団法人 日本薬理学会

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被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008185330
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5526166
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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