Involvement of the Renal Kallikrein-Kinin System in Furosemide-Induced Natriuresis in Rats

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This study examined whether the renal kallikrein−kinin system(KKS)is involved with furosemide−induced natriuresis in rats.Intravenous administration of furosemide(10 mg/kg)to anesthetized rats infused with physiological saline(saline)increased renal KK excretion as well as urine volume and urinary excretions of sodium, chloride and potassium.The change in the increase of renal KK excretion by furosemide at a dose of 1.0mg/kg relative to the control was larger than that of urine volume.Pretreatment with a B<SUB>2</SUB>−receptor antagonist, 8−[3−[N−[(E)−3−(6−acetamidopyridin−3−yl)acryloylglycyl]−N−methylamino]−2, 6−dichloro−benzyloxy]−2−methylquinoline(FR173657, 100mg/kg), significantly inhibited the furosemide−induced natriuresis by 58.6%.The effect of FR173657 on the furosemide−induced natriuresis was also examined in hypotonic saline−loading rats.Similar to the saline−loading rats, urinary excretion of sodium collected during the first 8 h in metabolic cages significantly reduced by 22.4% when FR173657(100mg/kg)was given concurrently with furosemide(100mg/kg)and hypotonic saline(5% of body wt.).These results indicate that furosemide increased renal KK excretion through a mechanism different from a washout mechanism and induced natriuresis partly through an augmentation of the renal KKS following the increase in renal KK excretion in both the saline− and hypotonic saline−loading rats.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(2), 133-139, 2000-10-01

    公益社団法人 日本薬理学会

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各種コード

  • NII論文ID(NAID)
    10008185522
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5549187
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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