Effects of Long-Term Treatment With Calcium Antagonists on Periarterial Nerve Function in the Mesenteric Artery of Spontaneously Hyupertensive Rats

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The effect of long−term treatment with dihydropyridine calcium antagonists(amlodipine, pranidipine, nicardipine)on the periarterial nerve function was investigated in the perfused mesenteric vascular bed isolated from spontaneously hypertensive rat(SHR).Male 8−week−old SHR received amlodipine(0.01% and 0.02%)and nicardipine(0.1%)in drinking water and pranidipine(0.0035% and 0.035%)in rat chow for 7 weeks.Mean blood pressure in SHR was significantly lowered by long−term treatment with each calcium antagonist.In mesenteric vascular preparations treated with each calcium antagonist, vasoconstriction induced by periarterial nerve stimulation(PNS;4, 8 and 12 Hz)was significantly smaller than that in non−treated SHR.The PNS(8 Hz)−evoked norepinephrine(NE)overflow in the perfusate was significantly decreased by amlodipine and pranidipine treatment, whereas nicardipine−treatment significantly enhanced the overflow of NE.In preparations with active tone produced by methoxamine and guanethidine, the PNS−induced vasodilation mediated by calcitonin gene−related peptide(CGRP)−containing(CGRPergic)vasodilator nerves was not affected by these drugs.These results suggest that long−term treatment of SHR with long−acting drugs, amlodipine and pranidipine, reduces sympathetic adrenergic nerve function but calcium antagonists have no effect on CGRPergic nerve function.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(2), 156-162, 2000-10-01

    公益社団法人 日本薬理学会

参考文献:  32件中 1-32件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008185617
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5549268
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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