The Scopolamine-Induced Impairment of Spatial Cognition Parallels the Acetylcholine Release in the Ventral Hippocampus in Rats

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We investigated the relationship between the induction of spatial cognition impairment in the 8−arm radial maze task and regional changes(ventral hippocampus(VH), dorsal hippocampus, frontal cortex, and basolateral amygdala nucleus)in brain acetylcholine(ACh)release using microdialysis in rats treated with muscarinic(M)receptor antagonists.In a behavioral study, two M<SUB>1</SUB> antagonists, scopolamine(0.5 mg/kg, i.p.and 20 μg, i.c.v.)and pirenzepine(80 μg, i.c.v.), but not an M<SUB>2</SUB> antagonist, AF−DX116(40−80 μg, i.c.v.), disrupted spatial cognition in the 8−arm radial maze task.In brain microdialysis with Ringer's solution containing 0.1 mM eserine sulfate, scopolamine and AF−DX116, but not pirenzepine, increased ACh release in the VH.Moreover, in the bilateral injection of scopolamine(2 μg/side), the VH and dorsomedial thalamus nucleus were important regions for scopolamine−induced impairment of spatial cognition.A simultaneous determination of the behavioral changes revealed that scopolamine(0.5 mg/kg, i.p.)markedly decreased the ACh contents and also increased the ACh release in all regions tested.Especially, the changes in the ACh release of the VH closely paralleled the induction of the scopolamine−induced impairment of spatial cognition.These results suggest that the blocking balance between M<SUB>1</SUB> and M<SUB>2</SUB> muscarinic receptor in the VH therefore plays a major role in the spatial cognition impairment induced by scopolamine in the 8−arm radial maze task.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(2), 163-173, 2000-10-01

    公益社団法人 日本薬理学会

参考文献:  36件中 1-36件 を表示

被引用文献:  4件中 1-4件 を表示

各種コード

  • NII論文ID(NAID)
    10008185650
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5549285
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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