Acetylcholine-Induced Smooth Muscle Contraction of Intrapulmonary Small Bronchi Is Augmented in Antigen-Induced Airway Hyperresponsive Rats

この論文にアクセスする

この論文をさがす

著者

抄録

Smooth muscle responsiveness of intrapulmonary small bronchi obtained from repeatedly antigen−challenged rats was compared with that from control animals to determine whether smooth muscle contractility of peripheral airways is augmented by such repeated challenge.In intact(non−permeabilized)smooth muscles of intrapulmonary bronchi, the acetylcholine(ACh)−induced contractile response was significantly augmented in the repeated challenge group, although 60−mM K<SUP>+</SUP>−induced contraction was within the normal level.In β−escin−permeabilized muscles, no significant difference between groups was observed in the Ca<SUP>2+</SUP>−induced contractile responses.Thus, augmented ACh−induced contraction of intact intrapulmonary small bronchial smooth muscle might be, at least in part, due to an enhanced ACh−mediated Ca<SUP>2+</SUP>−sensitizing signal.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(2), 221-224, 2000-10-01

    公益社団法人 日本薬理学会

参考文献:  13件中 1-13件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008185880
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5549430
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
ページトップへ