Non-competitive Inhibition of Kainate-Induced Currents by Diethylstilbestrol in Acutely Isolated Mouse CA1 Hippocampal Neurons

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抄録

The effect of a synthetic estrogen, diethylstilbestrol(DES), on kainate−induced currents was investigated in the hippocampal CA1 pyramidal neurons acutely dissociated from the mice using the nystatin−perforated patch−clamp recording configuration under voltage−clamp conditions.DES inhibited the current evoked by 100μM kainate in a concentration−dependent manner with a half−maximum inhibitory concentration of 8.8μM.The action of DES was voltage−independent.Since DES produced a suppression of the maximum response of the kainate concentration−response curve, the inhibition by DES of the kainate−induced current appears to be non−competitive.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(2), 225-228, 2000-10-01

    公益社団法人 日本薬理学会

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各種コード

  • NII論文ID(NAID)
    10008185894
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5549433
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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