The Parkinsonian Models. Invertebrates to Mammals.
-
- Kitamura Yoshihisa
- Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan
-
- Shimohama Shun
- Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan
-
- Akaike Akinori
- Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
-
- Taniguchi Takashi
- Department of Neurobiology, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan
Bibliographic Information
- Other Title
-
- Parkinsonian Models Invertebrates to Mammals
Search this article
Abstract
In contrast to Alzheimer’s disease, effective therapeutic options are available for Parkinson’s disease. Therapy of dopamine replacement such as levodopa improves the symptoms of this disease, but does not inhibit neurodegeneration in the substantia nigra. Numerous studies have suggested that endogenous and environmental neurotoxins, and oxidative stress may participate in this disease, but the detailed mechanisms are still unclear. Recent genetic studies in familial Parkinson’s disease and parkinsonism show several gene mutations. This new information regarding pathogenesis offers novel prospects for therapy. To develop novel neuroprotective drugs, it is necessary to have a model for each type of parkinsonism. This review summarizes current findings regarding parkinsonian models in vertebrates and invertebrates and discusses their value.
Journal
-
- The Japanese Journal of Pharmacology
-
The Japanese Journal of Pharmacology 84 (3), 237-243, 2000
The Japanese Pharmacological Society
- Tweet
Details 詳細情報について
-
- CRID
- 1390001204287861888
-
- NII Article ID
- 10008185965
-
- NII Book ID
- AA00691188
-
- COI
- 1:CAS:528:DC%2BD3cXosVKiu78%3D
-
- ISSN
- 13473506
- 00215198
-
- NDL BIB ID
- 5586747
-
- PubMed
- 11138723
-
- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I5586747
- https://api.elsevier.com/content/article/PII:S0021519819305025?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819305025?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/84/3/84_3_237/_pdf
- https://search.jamas.or.jp/link/ui/2001090525
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed