Effects of Higenamine on Regulation of Ion Transport in Guinea Pig Distal Colon

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Effects of higenamine on Na<SUP>+</SUP>, K<SUP>+</SUP> and Cl<SUP>-</SUP> transport were studied on stripped guinea pig distal colonic mucosa in vitro using Ussing chambers. Addition of 10<SUP>-5</SUP>M higenamine induced a biphasic change in short circuit current (Isc): a transient increase followed by a long-lasting decrease that was accompanied by an increase in transepithelial conductance (Gt). The initial phase with an increase in Isc was partially inhibited by serosal bumetanide and abolished by mucosal diphenylamine-2-carboxylate, a chloride channel blocker, indicating transient induction of Cl<SUP>-</SUP> secretion. The second phase with a decrease in Isc was composed of two effects: the inhibition of the amiloride-sensitive electrogenic Na<SUP>+</SUP> absorption and the stimulation of the bumetanide-sensitive K<SUP>+</SUP> secretion. However, the initial transient increase was not observed at the lower concentration of higenamine (10<SUP>-8</SUP>−10<SUP>-6</SUP>M). All the changes in Isc and Gt induced by higenamine were suppressed by the non-selective β-adrenergic receptor antagonist propranolol and by the β<SUB>2</SUB>-adrenergic receptor antagonist ICI-118, 551, but not by the β<SUB>1</SUB>-adrenergic-receptor-selective antagonist atenolol or by the α-antagonists phentolamine, prazosin and yohimbine. These results suggest that higenamine inhibits electrogenic Na<SUP>+</SUP> absorption and stimulates electrogenic K<SUP>+</SUP> and Cl<SUP>-</SUP> secretion through β<SUB>2</SUB>-adrenergic receptors in guinea pig distal colon.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(3), 244-251, 2000-11-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008185996
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5586762
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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