Effect of the Selective Adenosine A_1-Receptor Antagonist KW-3902 on Lipopolysaccharide-Induced Reductions in Urine Volume and Renal Blood Flow in Anesthetized Dogs

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著者

    • Yao Kozo YAO Kozo
    • Drug Department Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
    • OHNO Tetsuji
    • Drug Department Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
    • KARASAWA Akira
    • Drug Department Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.

抄録

We investigated the effects of KW-3902 (8-noradamantan-3-yl-1, 3-dipropylxanthine), a potent and selective adenosine A<SUB>1</SUB>-receptor antagonist, on lipopolysaccharide (LPS)-induced reduction of urine volume (UV) in anesthetized dogs, in comparison with those of furosemide. LPS was intravenously administered at a dose of 0.5mg/kg; and the heart rate (HR), systemic blood pressure (BP), renal blood flow (RBF) and UV were measured every 15min for 4h. Administration of LPS continuously decreased HR, BP, RBF and UV. KW-3902, furosemide or their corresponding vehicle was given as a bolus injection 5min after the LPS injection. Treatment with KW-3902 (1mg/kg, i.v.) ameliorated the LPS-induced decline of UV and RBF. Furosemide (3.2mg/kg, i.v.) tended to ameliorate the LPS-induced decline of UV but not RBF, the duration of the effect being shorter than that of KW-3902. These results suggest that KW-3902 can ameliorate the oliguria and the decrease in RBF during the early phase of LPS-induced shock. Endogenous adenosine may be involved in the endotoxin-induced oliguria via the adenosine A<SUB>1</SUB>-receptor.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(3), 310-315, 2000-11-01

    The Japanese Pharmacological Society

参考文献:  29件中 1-29件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008186227
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5586933
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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