Effect of the Selective Adenosine A_1-Receptor Antagonist KW-3902 on Tubuloglomerular Feedback in Radiocontrast-Media-Induced Nephropathy in Rats With Chronic Nitric Oxide Deficiency

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著者

    • Yao Kozo YAO Kozo
    • Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
    • Heyne Nils HEYNE Nils
    • Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.

抄録

To study the possible mechanism of renoprotective effects of adenosine A<SUB>1</SUB>-receptor antagonist against radiocontrast media (RCM)-induced nephropathy, we investigated the effects of adenosine A<SUB>1</SUB>-receptor antagonist on tubuloglomerular feedback (TGF) activity prior to and following application of RCM in chronic NO-depleted rats. TGF in NO-depleted rats was significantly enhanced compared with that in normal rats. After RCM application, the enhanced TGF was continued. A selective adenosine A<SUB>1</SUB>-receptor antagonist, KW-3902 (8-(noradamantan-3-yl)-1, 3-dipropylxanthine), inhibited the enhanced TGF. These results suggest that KW-3902 could inhibit TGF in chronic NO-depleted rats. Renoprotective effects by adenosine antagonists could be partly due to an inhibition of TGF via the blockade of the adenosine A<SUB>1</SUB>-receptor.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(3), 347-350, 2000-11-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008186391
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5587018
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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