Correction of Hyperglycemia and Insulin Sensitivity by T-1095, an Inhibitor of Renal Na^+-Glucose Cotransporters, in Streptozotocin-Induced Diabetic Rats

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We investigated the effects of T-1095 (3-(benzo[b]furan-5-yl)-2′, 6′-dihydroxy-4′-methylpropiophenone 2′-O-(6-O-methoxycarbonyl)-β-D-glucopyranoside), an orally active inhibitor of Na<SUP>+</SUP>-glucose cotransporter, on hyperglycemia and insulin resistance in skeletal muscle of streptozotocin (STZ)-induced diabetic rats. Chronic (4 weeks) administration of T-1095 as food admixture (0.01-0.1% wt/wt) suppressed the blood glucose level without affecting the food intake and body weight. In addition, the reduced 2-deoxyglucose uptake and lactate release in the soleus muscle of STZ rat was ameliorated by chronic treatment of T-1095. These data suggest that T-1095 improves insulin sensitivity in skeletal muscle through correction of hyperglycemia and has novel therapeutic potential for treatment of diabetes mellitus through removing glucose toxicity.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(3), 351-354, 2000-11-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008186407
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5587042
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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