Effects of Adrenergic α_2-Receptor Agonists on Urinary Bladder Contraction in Conscious Rats

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抄録

We investigated the effects of the adrenergic α<SUB>2</SUB>-receptor agonists clonidine, oxymetazoline and tizanidine on bladder contractions induced by infusing fluid into the bladders of conscious male rats. I.v. clonidine and oxymetazoline (both 0.01 to 0.1 mg/kg) caused bladder hyperactivity, expressed by shortening of the intercontraction interval. Tizanidine (0.1 mg/kg, i.v.) caused slight shortening of the intercontraction interval. The rank order of potency was clonidine=oxymetazoline >> tizanidine. Intrathecal (i.t.) injection of 10 μg clonidine and oxymetazoline, and intracerebroventricular (i.c.v) injection at 15 μg, produced almost the same pattern of bladder hyperactivity as that observed after i.v. injection of these drugs (0.03 mg/kg, i.v.). For all three administration routes of clonidine and oxymetazoline, i.v. idazoxan (0.3 mg/kg) exerted an inhibitory effect on the bladder hyperactivity induced by these drugs, except i.c.v injection of oxymetazoline. I.t. phenylephrine (30 μg) did not change the intercontraction interval. Although i.c.v. phenylephrine (15 μg) shortened the intercontraction interval, the potency was weaker than those of i.c.v. clonidine and oxymetazoline (15 μg). These results suggest that clonidine and oxymetazoline cause bladder hyperactivity by acting at adrenergic α<SUB>2</SUB> receptors in the micturition centers of the lumbosacral and supraspinal regions.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(4), 381-390, 2000-12-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008186532
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    5611954
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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