The Effects of Melatonin in Glutamate-Induced Neurotoxicity of Rat Cerebellar Granular Cell Culture

この論文にアクセスする

この論文をさがす

著者

抄録

In the present study, melatonin was tested in subsequent doses in glutamate induced neurotoxicity in cerebellar granular cell culture of rat pups. Glutamate at 10<SUP>-7</SUP>M was found to induce neuronal cell death. The dead cell score was 2.75±0.7 in the control, while it was found to be 35.12±1.8 in the glutamate-administered group (P<0.0001). Melatonin very potently blocked glutamate neurotoxicity at all doses tested, with 10<SUP>-3</SUP>M, the highest dose tested, being the most effective. Glutamate may exert a neuroprotective effect by blocking one or more steps of the oxidation cascade in neurons and this effect may be blocked by melatonin.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(4), 467-469, 2000-12-01

    The Japanese Pharmacological Society

参考文献:  15件中 1-15件 を表示

各種コード

  • NII論文ID(NAID)
    10008186913
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    5612181
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ