Ca^<2+>-Sensitization of Contraction in the h1 Calponin-Deficient Smooth Muscle

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著者

    • YOSHIMOTO Ryo
    • Department of Veterinaty Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo
    • HORI Masatoshi
    • Department of Veterinaty Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo
    • TAKAHASHI Katsuhito
    • Department of Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases
    • KATSUKI Motoya
    • Department of DNA Biology and Embryo Engineering, Institute for Medical Science, The University of Tokyo
    • OZAKI Hiroshi
    • Department of Veterinaty Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo
    • KARAKI Hideaki
    • Department of Veterinaty Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo

抄録

Role of h1 calponin on Ca<SUP>2+</SUP>-sensitivity of smooth muscle contraction was investigated using h1 calponin gene-deficient mice (CP−/−) and wild type mice (CP+/+). PGF<SUB>2α</SUB> induced a comparable force in intact aorta of CP+/+ and CP−/−. DPB showed similar effects to PGF<SUB>2α</SUB>. In membrane-permeabilized ileal smooth muscle, PDBu enhanced Ca<SUP>2+</SUP>-sensitivity of contraction comparably in CP+/+ and CP−/−. GTPγ-S showed similar effects. Our results suggest that h1 calponin does not regulate Ca<SUP>2+</SUP>-sensitivity in the contractile mechanism of smooth muscle.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 84(4), 474-475, 2000-12-01

    The Japanese Pharmacological Society

参考文献:  9件中 1-9件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008186945
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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