Pharmacokinetics of Paeoniflorin After Oral Administration of Shao-yao Gan-chao Tang in Mice

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Paeoniflorin, a monoterpene glycoside, is the principal bioactive component of Paeoniae Radix. The traditional prescription <i>Shao-yao Gan-chao Tang</i> (SGT; <i>Kampo</i>: <i>Shakuyaku-Kanzo-To</i>), which is composed of Paeoniae Radix and Glycyrrhizae Radix, has been widely used in China and Japan. Quantification of paeoniflorin in mouse plasma after oral administration of SGT (at a dose containing 10 mg/kg paeoniflorin) was achieved using a simple and rapid high-performance liquid chromatography method. The plasma concentration-time curves were fitted with mean terminal half-lives (t<sub>1/2</sub>) of 116.17 min. The maximum plasma concentration (C<sub>max</sub>) of paeoniflorin was 111.56 ng/ml, time to reach maximum concentration (t<sub>max</sub>) was 17.00 min, the area under the plasma concentration-time curve (AUC)<sub>0-t</sub> was 12293.42 ng · min/ml, clearance / bioavailability (CL/F) value was 644.74 ml/min · kg, apparent volume of distribution / bioavailability (V<sub>d</sub>/F) value was 103.05 l/kg, and the mean residence time (MRT) was 169.64 min. These results, together with the previously reported kinetic data of paeoniflorin after oral administration of Paeoniae Radix extract alone, indicated that absorption of paeoniflorin after oral administration of SGT was significantly greater than that after oral administration of Paeoniae Radix alone.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 88(3), 250-255, 2002-03-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008187657
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    6119411
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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