Failure of the Oxytocin-Induced Increase in Secretion of Urinary Kallikrein in Young Spontaneously Hypertensive Rats.

  • Majima Masataka
    Department of Pharmacology, Kitasato University School of Medicine
  • Adachi Keiichi
    Department of Pharmacology, Kitasato University School of Medicine
  • Ohno Takashi
    Department of Pharmacology, Kitasato University School of Medicine
  • Ogino Michiko
    Department of Pharmacology, Kitasato University School of Medicine
  • Saito Maki
    Department of Pharmacology, Kitasato University School of Medicine
  • Kizuki Kazuyuki
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo
  • Katsumata Osamu
    Department of Anatomy, Kitasato University School of Medicine
  • Yamashina Shohei
    Department of Anatomy, Kitasato University School of Medicine
  • Katori Makoto
    Department of Pharmacology, Kitasato University School of Medicine

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抄録

Urinary kallikrein excretion during oxytocin (OT) infusion were studied in anesthetized (sodium pentobarbital, 50 mg/kg, i.p.) young (4-weeks-old) spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). OT-infusion (30 nmol/kg/30 min) to WKY significantly increased urinary excretion of the active kallikrein from the basal levels (25.4±5.6 10-2 × AU/15 min, n=5) to 37.3±5.0 10-2 × AU/ 15 min (P<0.05, n=5) and 50.7±17.1 10-2× AU/15 min (P<0.05, n=5) 15 and 30 min after the start of OT-infusion, respectively. In SHR, OT-infusion did not increase the urinary excretion of active kallikrein, but did decrease the urine volume and sodium excretion. The concentration of the active kallikrein in the kidney of WKY was not changed by OT-infusion, but that of SHR was slightly increased. The OTinfusion resulted in significantly higher concentrations of the active kallikrein in SHR kidney than in WKY kidney. These results suggest that less excretion of urinary kallikrein in SHR during OT-infusion may be attributable to a lower response in the secretion of kallikrein from the kidney.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 71 (1), 11-19, 1996

    公益社団法人 日本薬理学会

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