ME3221, a Surmountable Angiotensin AT1-Receptor Antagonist, Prevents Hypertensive Complications in Aged Stroke-Prone Spontaneously Hypertensive Rats.
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- Nagura Jun
- Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
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- Hui Chen
- Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
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- Yamamoto Mikio
- Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
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- Yasuda Sumie
- Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
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- Abe Mitsuhiro
- Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
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- Hachisu Mitsugu
- Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
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- Konno Fukio
- Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
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The protective effects of ME3221, 3-met hoxy-2, 6-dimethyl-4-[[2''-(1H-tetrazol-5-yl)-1, 1''-biphenyl-4-yl]methoxy] pyridine, on aged (32-week-old) stroke-prone spontaneously hypertensive rats (SHRSP) were studied following long-term (for 8 months) oral administration. At a dose of 10 mg/kg/day, ME3221 suppressed the mortality and the hypertensive complications observed in control SHRSP: cerebral apoplexy (hemorrhage, and spongeform and malacia in the cerebral cortex), increased proteinuria, and total N-acetyl-β-D-glucosaminidase activity, and cardiac hypertrophy and pleural effusion. The protective activity of ME3221, a surmountable angiotensin AT1-receptor antagonist, was comparable to losartan, an insurmountable AT1-antagonist, and also to enalapril, an angiotensin-converting enzyme inhibitor. In addition, ME3221 reduced the systolic blood pressure more effectively than the two reference drugs.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 71 (1), 39-49, 1996
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679264601216
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- NII論文ID
- 10008188258
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK28XjtF2msLk%3D
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- ISSN
- 13473506
- 00215198
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- PubMed
- 8791170
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- PubMed
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- 使用不可