The Role of Histamine H_1-Receptors in the Anticonvulsive Effect of Morphine against Maximal Electroconvulsive Shock in Mice

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著者

    • ULUGOL Ahmet
    • Department of Pharmacology, Faculty of Medicine, Trakya University
    • DOKMECI Dikmen
    • Department of Pharmacology, Faculty of Medicine, Trakya University
    • DOKMECI Ismet
    • Department of Pharmacology, Faculty of Medicine, Trakya University

抄録

Morphine is known to release histamine from mast cells. It is also known that histamine receptors mediate some of morphine''s effects on the central nervous system. The contribution of H<SUB>1</SUB>-and H<SUB>2</SUB>-receptors to the effect of morphine on maximal electroconvulsive shock in mice was investigated in the present experiments. Morphine showed a dose-dependent anticonvulsive effect, but produced spontaneous clonic convulsions at higher doses (100 mg/kg, i.p.). The anticonvulsive effect of morphine (1 mg/kg, i.p.) was antagonized by histamine H<SUB>1</SUB>-receptor antagonists, dimethindene (0.1 mg/kg, i.p.), promethazine (0.4 mg/kg, i.p.) and pheniramine (30 mg/kg, i.p.), and naloxone (10 mg/kg, i.p.), but not by the H<SUB>2</SUB>-receptor antagonist ranitidine (10-50 μg, i.c.v.). These results show that morphine has an anticonvulsive effect via histamine H<SUB>1</SUB>-receptors against maximal electroconvulsive shock in mice.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 71(2), 109-112, 1996-06

    The Japanese Pharmacological Society

参考文献:  21件中 1-21件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008188499
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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