Inhibitory Effect of KW-4679, an Anti-allergic Drug, on Tachykinin-Mediated Airway Response Induced by Electric Vagal Stimulation in Guinea Pigs

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著者

    • SASAKI Yasuo
    • Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo, Co., Ltd.
    • ISHII Hidee
    • Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo, Co., Ltd.
    • OHMORI Kenji
    • Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo, Co., Ltd.

抄録

We examined the effect of KW-4679 ((<I>Z</I>)-11-[(3-dimethylamino)propylidene]-6, 11-dihydrodibenz[<I>b</I>, <I>e</I>]oxepin-2-acetic acid monohydrochloride), an anti-allergic drug, on the tachykinin-mediated airway response in guinea pigs. Electrical stimulation of the vagus nerve in atropine-treated and propranololtreated guinea pigs caused a 38.1% decrease in dynamic compliance (C<SUB>dyn</SUB>), which was suppressed by the combination of the tachykinin NK<SUB>1</SUB>-receptor antagonist (±)-CP-96345 and NK<SUB>2</SUB>-receptor antagonist SR 48968. KW-4679 at a dose of 3 mg/kg significantly reduced the decrease in C<SUB>dyn</SUB> (P<0.05). On the other hand, KW-4679 did not inhibit substance P or neurokinin A-induced decrease in C<SUB>dyn</SUB>. These results suggest that KW-4679 may inhibit the tachykininergic airway response by prejunctional inhibition of peripheral sensory nerves.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 71(2), 179-182, 1996-06

    The Japanese Pharmacological Society

参考文献:  15件中 1-15件 を表示

被引用文献:  7件中 1-7件 を表示

各種コード

  • NII論文ID(NAID)
    10008188722
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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