Nitric Oxide but Not Carbon Monoxide Is Involved in Spatial Learning of Mice

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著者

    • TOYODA Miwa
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
    • SAITO Hiroshi
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
    • MATSUKI Norio
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

抄録

The aim of the present study was to elucidate the role of carbon monoxide (CO) in learning and to compare it with that of nitric oxide (NO). Effects of an inhibitor of heme oxygenase which produces CO, Zn-protoporphyrin IX, on passive avoidance learning and spatial learning in mice were examined using step through, step down and water maze tests. Zn-protoporphyrin IX (10, 20 nmol, i.c.v.) affected neither type of learning. In contrast, <I>N</I>-ω-nitro-L-arginine (40 nmol, i.c.v.), an inhibitor of NO synthase, impaired spatial learning, but not passive avoidance learning. These results suggest that NO but not CO is involved in spatial learning.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 71(3), 205-211, 1996-07

    The Japanese Pharmacological Society

参考文献:  23件中 1-23件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008188894
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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