Role of Platelet-Activating Factor and Prostanoids in Hemodynamic Changes in Rat Experimental Endotoxic Shock

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The present experiments were conducted to elucidate the role of platelet-activating factor (PAF) and cyclooxygenase products in the cardiovascular responses to endotoxin in anesthetized rats. Endotoxin (10 mg/kg, i.v.) induced hypotension that was accompanied by a decrease in cardiac output and an increase in calculated total peripheral resistance, suggesting that this hypotension mainly resulted from the reduced cardiac output. The endotoxin-induced decrease in cardiac output and hemoconcentration was significantly attenuated by TCV-309 (a PAF receptor antagonist), ibuprofen (a cyclooxygenase inhibitor) or S-1452 (a thromboxane A<SUB>2</SUB>/prostaglandin H<SUB>2</SUB>-receptor antagonist). During the 3-hr observation period following endotoxin administration, ibuprofen and S-1452 showed only early protection and TCV-309 showed late attenuation of the endotoxin-induced hypotension. Tachycardiac responses to endotoxin were only blocked by ibuprofen but not by TCV-309 or S-1452. These results suggest that both PAF and cyclooxygenase product(s), including thromboxane A<SUB>2</SUB>, mediate the decrease in cardiac output and hypotension in rat experimental endotoxic shock. Cyclooxygenase product(s) other than thromboxane A<SUB>2</SUB> or prostaglandin endoperoxide may be involved in the endotoxin-induced increase in heart rate.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 71(3), 247-253, 1996-07

    The Japanese Pharmacological Society

参考文献:  29件中 1-29件 を表示

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各種コード

  • NII論文ID(NAID)
    10008189049
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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