Characteristic Upregulation of Dopamine D1-Receptor in Rat Striatum after 6-Hydroxydopamine Treatment.
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- Iwata Shin-ichi
- Department of Pharmacology, Faculty of Medicine, University of Kagoshima
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- Shimizu Takao
- Department of Pharmacology, Faculty of Medicine, University of Kagoshima
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- Nomoto Masahiro
- Department of Pharmacology, Faculty of Medicine, University of Kagoshima
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- Fukuda Takeo
- Department of Pharmacology, Faculty of Medicine, University of Kagoshima
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Abstract
We measured the number of D1-receptors (Bmax) in the striatum whose dopaminergic terminals were destroyed to various degrees by 6-hydroxydopamine (6-OHDA) to clarify the relationship between the degree of denervation and the change in Bmax for D1-receptor. Rats were sacrificed 28 days after 6-OHDA treatment, and [3H]SCH23390 (R(+)-7-chloro-8-hydroxy-3-methyl-l-phenyl-2, 3, 4, 5-tetrahydro-1H-3-benzazepine) binding capacity and monoamine content were measured in striatal homogenate. Bmax was significantly upregulated when dopamine content was reduced to less than 5% of that in the vehicletreated striatum. In contrast, it was significantly decreased when dopamine content was 5—25% of that in the vehicle-treated striatum. The D1-receptors showed either upregulation or downregulation depending on the degree of denervation.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 71 (3), 255-258, 1996
The Japanese Pharmacological Society
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Details
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- CRID
- 1390001204285209984
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- NII Article ID
- 10008189079
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK28XksFOnt78%3D
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- ISSN
- 13473506
- 00215198
- http://id.crossref.org/issn/00215198
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- PubMed
- 8854208
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed