Effect of Fluvoxamine on 5-Hydroxytryptamine Uptake, Paroxetine Binding Sites and Ketanserin Binding Sites in the Japanese Monkey Brain and Platelets, In Vivo and In Vitro.
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- Goto Shinichiro
- Department of Pharmacology, Oita Medical University
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- Egashira Toru
- Department of Pharmacology, Oita Medical University
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- Wada Yuji
- Department of Pharmacology, Oita Medical University
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- Takayama Fusako
- Department of Pharmacology, Oita Medical University
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- Yamanaka Yasumitsu
- Department of Pharmacology, Oita Medical University
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We investigated the in vitro effects of fluvoxamine on 3H-paroxetine binding and 3H-monoamine uptake in monkey cerebral cortex in comparison with those of other antidepressants. Fluvoxamine selectively inhibited 3H-5-hydroxytryptamine (5-HT) uptake and 3H-paroxetine binding. However, it did not alter 3H-norepinephrine or 3H-dopamine uptake. In addition, we examined the effects of chronic treatment with fluvoxamine (5 mg/kg per day, p.o.) on 5-HT uptake sites that bind 3H-paroxetine and 5-HT2 receptors that bind 3H-ketanserin, in monkey brains and platelets. Chronic treatment with fluvoxamine affected neither the paroxetine binding sites nor the kentanserin binding sites of the brains and platelets. These results suggest that long-term treatment with fluvoxamine does not affect either the 5-HT uptake sites or 5-HT2-receptors of 5-HT neurons in monkey brain in spite of its strong inhibitory effect on 5-HT uptake in vitro.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 71 (4), 291-298, 1996
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679264412416
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- NII論文ID
- 10008189209
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK28XltlKlsro%3D
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- ISSN
- 13473506
- 00215198
- http://id.crossref.org/issn/00215198
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- PubMed
- 8886926
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可