Effect of Fluvoxamine on 5-Hydroxytryptamine Uptake, Paroxetine Binding Sites and Ketanserin Binding Sites in the Japanese Monkey Brain and Platelets, In Vivo and In Vitro

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We investigated the in vitro effects of fluvoxamine on <SUP>3</SUP>H-paroxetine binding and <SUP>3</SUP>H-monoamine uptake in monkey cerebral cortex in comparison with those of other antidepressants. Fluvoxamine selectively inhibited <SUP>3</SUP>H-5-hydroxytryptamine (5-HT) uptake and <SUP>3</SUP>H-paroxetine binding. However, it did not alter <SUP>3</SUP>H-norepinephrine or <SUP>3</SUP>H-dopamine uptake. In addition, we examined the effects of chronic treatment with fluvoxamine (5 mg/kg per day, p.o.) on 5-HT uptake sites that bind <SUP>3</SUP>H-paroxetine and 5-HT<SUB>2</SUB> receptors that bind <SUP>3</SUP>H-ketanserin, in monkey brains and platelets. Chronic treatment with fluvoxamine affected neither the paroxetine binding sites nor the kentanserin binding sites of the brains and platelets. These results suggest that long-term treatment with fluvoxamine does not affect either the 5-HT uptake sites or 5-HT<SUB>2</SUB>-receptors of 5-HT neurons in monkey brain in spite of its strong inhibitory effect on 5-HT uptake in vitro.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 71(4), 291-298, 1996-08-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008189209
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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