Negative Chronotropic and Inotropic Effects of U-92032, a Novel T-Type Ca^<2+> Channel Blocker, on the Isolated, Blood-Perfused Dog Atrium

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We investigated the effects of U-92032 ((7-((bis-4-fluorophenyl)methyl)-1-piperazinyl)-2-2(2-hydroxyethylamino)-4-(1-methylethyl)-2, 4, 6-cycloheptatrien-l-one), a novel T-type Ca<SUP>2+</SUP> channel blocker, on sinus rate and atrial contractile force in the isolated, blood-perfused atrium of the dog. U-92032 (1 to 300 nmol) induced negative chronotropic and inotropic responses in a dose-dependent manner, and the percentage decrease in sinus rate was less than that in atrial contractile force. Atropine did not affect the negative responses to U-92032. These results suggest that U-92032, a T-type Ca<SUP>2+</SUP> channel blocker, simultaneously decreases the sinus rate and atrial force as do L-type Ca<SUP>2+</SUP> channel blockers in the isolated dog atrium.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 71(4), 333-335, 1996-08-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008189345
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • データ提供元
    CJP書誌  J-STAGE 
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