Negative Chronotropic and Inotropic Effects of U-92032, a Novel T-Type Ca2+ Channel Blocker, on the Isolated, Blood-Perfused Dog Atrium.
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- Lakhe Manoj
- Department of Pharmacology, Shinshu University School of Medicine
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- Furukawa Yasuyuki
- Department of Pharmacology, Shinshu University School of Medicine
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- Yonezawa Takanori
- Department of Pharmacology, Shinshu University School of Medicine
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- Nagashima Yoshito
- Department of Pharmacology, Shinshu University School of Medicine
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- Hirose Masamichi
- Department of Pharmacology, Shinshu University School of Medicine
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- Chiba Shigetoshi
- Department of Pharmacology, Shinshu University School of Medicine
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We investigated the effects of U-92032 ((7-((bis-4-fluorophenyl)methyl)-1-piperazinyl)-2-2(2-hydroxyethylamino)-4-(1-methylethyl)-2, 4, 6-cycloheptatrien-l-one), a novel T-type Ca2+ channel blocker, on sinus rate and atrial contractile force in the isolated, blood-perfused atrium of the dog. U-92032 (1 to 300 nmol) induced negative chronotropic and inotropic responses in a dose-dependent manner, and the percentage decrease in sinus rate was less than that in atrial contractile force. Atropine did not affect the negative responses to U-92032. These results suggest that U-92032, a T-type Ca2+ channel blocker, simultaneously decreases the sinus rate and atrial force as do L-type Ca2+ channel blockers in the isolated dog atrium.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 71 (4), 333-335, 1996
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679264418048
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- NII論文ID
- 10008189345
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK28XltlKlsrc%3D
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- ISSN
- 13473506
- 00215198
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- PubMed
- 8886931
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 使用不可