The Mode of Inhibitory Action of α-Mangostin, a Novel Inhibitor, on the Sarcoplasmic Reticulum Ca^<2+>-Pumping ATPase from Rabbit Skeletal Muscle

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著者

    • FURUKAWA Ken-ichi
    • Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University
    • SHIBUSAWA Kazuki
    • Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University
    • CHAIRUNGSRILERD Nattaya
    • Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University
    • OHTA Tomihisa
    • Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tohoku University
    • NOZOE Shigeo
    • Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tohoku University
    • OHIZUMI Yasushi
    • Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University

抄録

α-Mangostin, the principal ingredient of the fruit hull of <I>Garcinia mangostana</I>, caused a concentration-dependent decrease in the activities of both Ca<SUP>2+</SUP>-ATPase and Ca<SUP>2+</SUP>-transport of the sarcoplasmic reticulum from rabbit skeletal muscle with an IC<SUB>50</SUB> value of 5 μM. Neither Ca<SUP>2+</SUP> release nor other enzyme activities were affected by α-mangostin. Kinetic analysis of the inhibitory effects of α-mangostin on Ca<SUP>2+</SUP>-ATPase suggests that the inhibition of the ATPase is a noncompetitive-type with respect to ATP or Ca<SUP>2+</SUP>. α-Mangostin may become a useful pharmacological tool for clarifying the physiological functions of Ca<SUP>2+</SUP>-pumping ATPase and sarcoplasmic reticulum.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 71(4), 337-340, 1996-08-01

    The Japanese Pharmacological Society

参考文献:  11件中 1-11件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10008189358
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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