Effects of Sematilide, a Novel Class III Antiarrhythmic Agent, on Delayed Rectifier K^+ Current in Guinea Pig Atrial Myocytes

この論文にアクセスする

この論文をさがす

著者

    • ISHII Yasunori
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
    • MURAKI Katsuhiko
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
    • IMAIZUMI Yuji
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
    • WATANABE Minoru
    • Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University

抄録

Effects of sematilide, a novel class III antiarrhythmic agent, on the delayed rectifier K<SUP>+</SUP> current (I<SUB>K</SUB>) were examined in guinea pig atrial myocytes using a voltage clamp technique. Sematilide inhibited both time-dependent outward current upon depolarization and tail currents (I<SUB>K-tail</SUB>) at −40 mV. The concentration of sematilide required for a 50% decrease in I<SUB>K-tail</SUB> was approximately 50 μM. The sematilidesensitive current obtained using a triangular voltage command exhibited marked inward rectification and had the maximum amplitude at −30 mV. These results suggest that sematilide inhibits rapidly activating I<SUB>K</SUB> in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 71(4), 361-365, 1996-08-01

    The Japanese Pharmacological Society

参考文献:  14件中 1-14件 を表示

各種コード

  • NII論文ID(NAID)
    10008189432
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • データ提供元
    CJP書誌  J-STAGE 
ページトップへ