Histamine-Induced Cortisol Secretion from Bovine Adrenocortical Cells: Co-incubated with Bovine Adrenal Medullary Cells

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Histamine at concentrations higher than 10<SUP>-9</SUP> M significantly elicited cortisol secretion from bovine adrenocortical (BAC) cells co-incubated with bovine adrenal medullary (BAM) cells, suggesting that BAM cells are responsible for histamine-induced cortisol secretion. Cortisol secretion from BAC cells coincubated with BAM cells was also elicited by both an H<SUB>1</SUB> agonist, 2-methylhistamine, and an H<SUB>2</SUB> agonist, 4-methylhistamine. However, 4-methylhistamine was much less effective than 2-methylhistamine. Histamine-induced cortisol secretion was inhibited not only by H<SUB>1</SUB> antagonists (pyrilamine and diphenhydramine) but also by H<SUB>2</SUB> antagonists (cimetidine and ranitidine). Histamine effectively increased <SUP>45</SUP>Ca uptake and IP<SUB>3</SUB> production in BAM cells. These responses were antagonized by the H<SUB>1</SUB> antagonist but not by the H<SUB>2</SUB> antagonist. Histamine-induced cortisol secretion from BAC cells co-incubated with BAM cells was inhibited by β-adrenoceptor antagonists, propranolol and timolol, as well as an NK<SUB>1</SUB>-receptor antagonist, DArg<SUP>1</SUP>-D-Trp<SUP>7, 9</SUP>-Leu<SUP>11</SUP>-substance P. These results indicate that histamine can induce cortisol secretion from BAC cells at physiological concentrations through H<SUB>1</SUB> receptors on BAM cells, and catecholamine and substance P may participate in histamine-induced cortisol secretion.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 75(2), 115-121, 1997-10-01

    The Japanese Pharmacological Society

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各種コード

  • NII論文ID(NAID)
    10008189493
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00215198
  • NDL 記事登録ID
    4326408
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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