Inhibitory Effect of Lomerizine, a Diphenylpiperazine Ca2+-Channel Blocker, on Ba2+ Current through Voltage-Gated Ca2+ Channels in PC12 Cells.

• Watano Tomokazu

  Department of Pharmacology, New Drug Discovery Research Laboratory, Kanebo Ltd.

• Hara Hideaki

  Department of Pharmacology, New Drug R & D Laboratory, Kanebo Ltd.

• Sukamoto Takayuki

  Department of Pharmacology, New Drug R & D Laboratory, Kanebo Ltd.

書誌事項

タイトル別名

• Inhibitory Effect of Lomerizine a Diphe

抄録

We investigated the effect of lomerizine, an anti-migraine drug, on the Ba²⁺ current through voltage-gated Ca²⁺ channels in rat pheochromocytoma (PC12) cells using a whole-cell voltage-clamp technique. Lomerizine inhibited the Ba²⁺ current with an IC₅₀ value of 1.9 μM. Lomerizine and nicardipine were > 4 times more potent than flunarizine, diltiazem, verapamil and dimetotiazine. The time course of inactivation induced by lomerizine was similar to that induced by nicardipine and flunarizine. These data indicate that lomerizine may inhibit the Ca²⁺ channel in a similar manner to nicardipine and flunarizine, and its potency is almost equal to that of nicardipine.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 75 (2), 209-213, 1997

  公益社団法人 日本薬理学会

キーワード

• Lomerizine
• Voltage-gated Ca<SUP>2+</SUP> channel
• PCl2 cell

詳細情報

• CRID: 1390001204285271552
• NII論文ID: 10008189800
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.75.209
• COI: 1:CAS:528:DyaK2sXntVKmu78%3D
• ISSN: 13473506
• ISSN: 00215198
• ISSN: http://id.crossref.org/issn/00215198
• NDL書誌ID: 4326422
• PubMed: 9414039
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4326422
• Web Site: https://search.jamas.or.jp/link/ui/1998151449
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可